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Plasma membrane disruption has long been known to be one of the principle mechanisms of cell cryodamage [46].
The hypothesis of membrane disruption has also been investigated.
Membrane disruption has been suggested as a mechanism by which Aβ might inflict damage to neuronal cells.
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Although cellular internalization and membrane disruption have been observed in the TEM images, any change in the morphology of the cells cannot be predicted from the images.
Furthermore, disruption of recycling alters junction proteins at the plasma membrane and this disruption has been associated with tumor formation and inflammatory diseases (Brennan et al., 2010; Utech et al., 2010).
The disruption has rattled industry officials.
Every disruption has its losers and winners.
Disruption has now been cleared.
Early traumas such as damage to the osseous spiral lamina, basilar membrane rupture, and lateral wall disruption have all been shown to have occurred during human cochlear implantation [ 43– 45] and animal models of implantation [ 46, 47] and are likely to manifest as immediate hearing loss.
Membrane disruption appears to have a direct effect on apoptosis, and thus these two mechanisms could actually be working together to induce amylin-mediated cytotoxicity.
We found that cytoskeletal disruption had no effect on AQP1 diffusion in the plasma membrane, but that diffusion was increased greater than fourfold in protein de-enriched blebs.
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