Sentence examples for mediated predominantly through from inspiring English sources

However, inclusion of the indirect effect of dose on 12-wk pain, mediated predominantly through 6-wk pain (βindirect = −0.09), yielded a statistically significant total effect at 12 weeks (β = −0.12).

These findings indicate that like morphine, the antinociception induced by fentanyl may be mediated predominantly through μ1-opioid receptors at both supraspinal and spinal sites in mice.

EGF effects are mediated predominantly through the EGF receptor (EGF-R).

This study indicates that Matricaria chamomilla possesses antidiarrhoeal, antisecretory and antispasmodic activities mediated predominantly through K+-channels activation along with weak Ca++ antagonist effect.

Transcriptional regulation of Ccl5 is mediated predominantly through six short regulatory elements contained within a region of the Ccl5 promoter spanning ∼300 base pairs (Fessele et al., 2002).

Consequently, exogenous IL-32α-induced TNFα production was mediated predominantly through the activation of NF-κB and the MEK-ERK signaling pathway.

We suggest that the exposure of this β-edge in Vκ domains may explain why light-chain deposition disease is mediated predominantly by κ antibodies.

Endothelial cells mediate vasodilatation predominantly through the production of NO.

Antibodies that achieve efficacy wholly or predominantly through Fc-mediated mechanisms, represent rich opportunities for future therapeutics in oncology.

A member of the signal transducer and activator of transcription family [ 84], Stat6 is activated predominantly through JAK-mediated tyrosine phosphorylation in response to IL-4 or IL-13.

The activity of both caspase-9 and caspase-3/7 were significantly elevated at 10, 20 and 40 μg/mL AMEAE treatment, while activation of caspase-8 was only triggered at higher concentrations of 20 and 40 μg/mL, suggesting that AMEAE induced apoptosis predominantly through mitochondrial-mediated intrinsic pathway.