Sentence examples for mediated largely through from inspiring English sources

These processes are thought to be mediated largely through excess production of proinflammatory and catabolic mediators, among which prostaglandin E2 (PGE2) is considered a critical mediator in the pathophysiology of the disease [ 2, 3].

A mediation analysis indicated that the effect of the leaflet on intention was mediated largely through its effects on anticipated peace of mind, perceived vulnerability to CRC, perceived disgust, and perceived efficacy of the test.

For example, moderate exercise training alters oxidative homeostasis by reducing basal levels of oxidative damage [60], and by increasing resistance to oxidative stress, mediated largely through increased endogenous antioxidant defenses [60,62].

Given the complexity in the metabolic alterations of cancer cells mediated largely through alterations in mitochondrial function, further research is required to identify more efficient strategies for cancer treatment involving the use of small molecules targeting mitochondrial metabolism.

Further understanding the complexity in the metabolic alterations of cancer cells, mediated largely through alterations in mitochondrial function, may pave the way to identify more efficient strategies for cancer treatment involving the use of small molecules targeting mitochondria, cholesterol homeostasis/trafficking and specific metabolic pathways.

In an election conducted almost exclusively through carefully choreographed spectacles and mediated largely through screens, a cross on a ballot does little more than alienate us from our own political agency.

CD8+ T-cells may mediate tumor eradication largely through direct CTL activity, but the role of CD4+ T-cells and other cells of the immune system is less clear.

In view of our results, it remained unclear whether cell type-specific binding is largely mediated through tethering of shared factors to regulatory elements through protein-protein interaction with cell type-specific factors, or whether cell type-specific binding of shared TFs requires direct binding to DNA and, therefore, represents classical TF functionality.

These processes are thought to be largely mediated through excess production of proinflammatory and catabolic mediators.

Although the direct effect of smoking on neonatal mortality is weak, its effects (on mortality) appear to be largely mediated through reduced fetal growth and, to a lesser extent, through shortened gestation.

Host-seeking in mosquitoes is facilitated through a range of sensory cues and is largely mediated through the chemoreception of host-associated kariomones.