Sentence examples for mediated mainly through from inspiring English sources

These results suggest that NK-mediated control of melanoma cells is mediated mainly through certain receptors.

Conclusion: Placenta previa triples the rate of neonatal mortality, which is mediated mainly through preterm birth.

Recent electrophysiological experiments demonstrated that DA effects in the MPOA of quail are mediated mainly through the activation of α2-noradrenergic receptors.

Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through epigenetic priming of cancer-initiating cells, suggesting that genetic lesions that initiate the cancer process might be dispensable for the posterior tumor progression and maintenance.

Given that sensitization of the sensory neurons mediated mainly through the EP4 receptors [10] it has been suggested that the prostanoid EP4 receptor may be a potential target for the treatment of pain [11].

LLp-1b could significantly shorten APTT and increased FIB content, which indicated that its effects were mediated mainly through the intrinsic coagulation pathway and increasing the content of FIB [15].

Transport of small solutes (<800 Da) across the OM is mediated mainly by passive diffusion through the water-filled channels of trimeric β-barrel porin proteins.

There is no doubt that the action in vivo is mediated mainly, if not completely, through mechanisms other than the physicochemical inhibition of crystal dissolution, as was initially postulated.

The anti-osteogenic effect of sclerostin is thought to be mediated mainly by inhibition of Wnt signaling through Lrp5/6 within osteoblasts.

The powerful anti-osteogenic effect of sclerostin is thought to be mediated mainly by inhibition of Wnt-signaling through Lrp5/6 within osteoblasts by disrupting the Wnt induced frizzled/Lrp complex formation, although sclerostin was first found to inhibit not Wnt, but the action of murine and human BMPs in vitro [9], [10].

Hypoxia is a characteristic of invasive cancers that can lead to the development of an aggressive phenotype through a mechanism mediated mainly by HIF-1 α, which includes cell immortalisation and dedifferentiation, pH regulation, autocrine growth/survival, angiogenesis, invasion/metastasis, and resistance to chemotherapy (Semenza, 2006, 2009; Grothey and Galanis, 2009).