Structural equation modeling revealed that the indirect effects of catchment agriculture on the riparian denitrification potential and N2O production rate were mediated primarily through soil NO3–.
Moreover, this study suggests that it is possible to predict trait loss from plant communities in forests where degradation is mediated primarily through subsistence agriculture and resource extraction.
The disruption of endothelial barrier function by histamine, however, seems to be mediated primarily through H1R via the small GTPase RhoA and its associated kinase ROCK, as treatment with a ROCK inhibitor protects from anaphylactic shock in experimental models [75].
The activation of antimicrobial peptides gene expression in particular, and the non-specific immune system in general, by feeding sulphated polysaccharides (FRSE) is thought to be mediated primarily through their recognition by specific receptors.
It has been repeatedly shown that glucocorticoid-stimulated muscle protein breakdown is mediated primarily through ubiquitin-proteasome-dependent proteolysis and other calcium-dependent protein degradation pathways [43].
Cell invasion is regulated in part by cell-ECM interactions mediated primarily through integrin receptors expressed on the cell surface [33].
The inhibition of bone formation by Dkk1 and sclerostin is thought to be mediated primarily through inhibition of wnt-signaling in osteoblasts.
Acute treatment with HOE-140, however, fails to produce such effects, suggesting that enalapril-induced endothelial cell protection is mediated primarily through inhibition of the synthesis of angiotensin II, rather than a decreased degradation of bradykinin in the vascular wall.
The correlation in the pathways and cytokines modulated by Vav deletion and Themis2 over-expression suggest that the functional impact of Themis2 on these events is mediated primarily through its interaction with Vav.
Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota (PKCι) enzyme antagonizes polyglutamine-induced cell death through induction of the ERK signaling pathway.
This process is mediated primarily through 24 nt short-interfering RNAs (siRNAs).
