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A member of the signal transducer and activator of transcription family [ 84], Stat6 is activated predominantly through JAK-mediated tyrosine phosphorylation in response to IL-4 or IL-13.
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In contrast, OA patients had fewer phospho-epitopes activated, predominantly in the CD8+ T cell compartment (Table 1).
In general, these results suggest that stories containing a deception element activated predominantly left inferior and medial frontal gyrus.
In contrast to Bim, Puma appears to be activated predominantly by transcriptional mechanisms.
CaMK, on the other hand, is activated predominantly at frequencies higher than 2 Hz.
WapCre is activated predominantly in the luminal compartment (Wagner et al, 1997).
1 In neurons, caspases are predominantly activated through the intrinsic pathway, that involves cytochrome c release from mitochondria and formation of the apoptosome, which results in activation of caspase 9 and subsequent activation of downstream caspases.
In our study, activated T lymphocytes can trigger BMMSC apoptosis, predominantly through the FasL/Fas pathway, supporting the notion that Fas antigen is involved in BMMSC death in vivo [40].
Among S1PRs, Gi-associated S1PR1 (33) is mainly expressed in the liver (34), and PTX pretreatment inhibited exogenous S1P-induced AKT phosphorylation in primary cultured hepatocytes (data not shown), suggesting that S1P may activate AKT through predominantly S1PR1.
Resting healthy T cells died predominantly through activating ATM (Fig 2) whereas RA T cells lack availability of that mechanism and seem to resort to alternative means of DNA surveillance.
Most of these were associated with bioinformatically predicted NMD activating features, predominantly upstream open reading frames (uORFs).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com