Sentence examples for mediated mostly through from inspiring English sources

The androgen-signaling pathway, mediated mostly through the androgen receptor (AR), plays a critical role in the regulation of prostate cancer cell growth and survival [ 3, 4].

Although many reports have described the regulation of the miR-34 family as being mediated mostly through the p53 signaling pathway [ 15- 17, 39], miR-34b/c could also be regulated by DNA methylation of CpG islands [ 18, 40, 41].

Interestingly, oxidative damage on neurons is mediated mostly through apoptosis, and dietary components with high antioxidant capacities have been shown to prevent or at least delay the processes leading up to neurodegeneration.

This type of genetic asymmetry has been observed in other populations, including Brazilian individuals of African ancestry, as the analysis of sex specific and autosomal markers has revealed evidence for substantial European admixture that was mediated mostly through men [ 56].

They have the propensity to spread easily between humans (hand carriage, contaminated food and water) and to acquire genetic material through horizontal gene transfer, mediated mostly by plasmids and transposons.

Effects of insulin on glycemia lowering are mediated mostly by an increase in cellular uptake of glucose through GLUT 4 translocation to the membrane.

Therefore the effects previously assigned to T lymphocytes could indeed be mediated mostly by NK cells.

VRK2A effects are mediated mostly by its interactions with scaffold proteins that affect cellular signaling.

Therefore, FAD-induced cancer cell death is mediated mostly by caspase-dependent apoptosis.

Data suggests that pruritic responses are mediated mostly by B2 receptors.

This effect was mediated mostly via PPAR alpha, but also partially via PPAR gamma [ 57].