Sentence examples for mediate this pathway from inspiring English sources

We conjectured that a series of unknown signal transduction factors mediate this pathway, which remain to be investigated.

To see if TRAF3 and TRAF5 also mediate this pathway, we examined the activation of IFN-β production in cells after transfection with poly dA dT following the knockdown of TRAF3 or TRAF5 expression.

The authors found that mortality was significantly greater among subjects in the highest CMV IgG quartile, compared with the lowest quartile and that this association remained significant after controlling for several covariates including CRP, suggesting that CRP did not mediate this pathway [50].

Angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are two classes of drugs used to mediate this pathway and both classes have been studied in sarcopenia.

Central to this mechanism are the Argonaute (Ago) proteins, which mediate this pathway by facilitating the interaction between miRNAs and their target mRNAs (Höck and Meister, 2008; Bartel, 2009).

In endothelial cells, PI3K, Akt kinase, ERK1/2, striatin, and phosphorylation of eNOS have been described to be required for ERα MISS, whereas in vascular smooth muscle cells, expression and activity of several phosphatases such as MKP-1, SHP-1, PTEN, and PP2A mediate this pathway (Ueda & Karas, 2013).

Extensive effort is also being devoted to developing small-molecule inhibitors against key enzymes that mediate this signaling pathway and testing their potency in models of pancreatic cancer.

Therefore, the inhibition of Ubc13 by small compounds could limit the response to viral infections mediated through this pathway.

We preliminarily attempted to measure the complex I activity in cybrids to test if the toxic effect of 2,5-HD was mainly mediated through this pathway, which is impaired by the LHON mutations.

The toxicity of neuroserpin polymers may also be mediated through this pathway.

Reduction in VRK2A levels results in an increased response mediated by this pathway.