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Our results suggest that Sp1 binding site can function as a distinct TGF-beta responsive element for TGF-beta mediated promoter expression and Sp1 per se can mediate this response.
The molecular mechanisms that mediate this response occur across many highly complex biological regulatory levels that are incompletely understood.
The aim of the present study was to investigate O. ostertagi's ability to induce NETs of bovine neutrophils and delineate the mechanisms that mediate this response, furthering our understanding of O. ostertagi pathogenesis and host responses and potentially revealing novel immunological treatment targets.
Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the prostate and oestrogen receptor (ER) α is required to mediate this response.
We used RT-PCR and pharmacology to identify candidate ion channels that may mediate this response.
AT2 and LGR7, together with high expression level of iNOS, are potential candidates to mediate this response.
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The zinc sensors and regulatory factors responsible for mediating this response to zinc depletion ARE yet unknown in C. reinhardtii.
This Coolidge effect seems to be attenuated when mucus trails are excluded, which suggests that a chemical or textural cue may be responsible for mediating this response to sperm competition.
The present study was designed to determine the intracellular signaling pathway mediating this response.
The process mediating this response is known as neurovascular coupling and presence and amplitude of a typical, biphasic response are established indicators for autoregulatory quality50.
Thus, the present study was designed to evaluate central ACTH's effect on food intake and to elucidate the mechanism mediating this response using broiler chicks.
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