It is interesting to note that substitutions at A157 for the estrogen receptor has profound effects over the affinity of this receptor to HRE sequences in analogy to what occurs upon the substitutions of G157 for TR, although these residues, themselves, do not contact directly any nucleotide, confirming the stereochemical topological influence mediated by this position.
Thus, P1-nesprin-3 interactions occurring at the outer nuclear membrane are likely to fulfill functions other than shaping the morphology or mediating the positioning of nuclei along the muscle fiber.
In this study, we showed that Sun1 is selectively expressed in Purkinje cells and mediates the positioning of the nucleus and cellular morphogenesis (Figs 3- 5), whereas migration of granule neurons is not affected by the depletion of Sun1 or Sun2 (Fig. 1D).
One possibility is that in wild type plants, MOP1 directly or indirectly mediates nucleosome position at the TSS of some genes, and this positioning becomes disrupted in the absence of functional MOP1.
We demonstrate here that the microtubule cytoskeleton gradually transitions from a radial to linear organization during neurulation and that microtubules function in conjunction with the polarity protein Pard3 to mediate centrosome positioning.
Bacterial proteins present in the membrane of the inclusion and directed towards the cytoplasmic face of the inclusion membrane are likely to mediate early (positioning), mid (organelle fusion, survival control) and late (survival control, egress) effects and thereby critically regulate replication.
"If I keep putting myself in this position, Rocco Mediate keeps telling me I'll win by accident -- I'll birdie the last three holes or someone will bogey the last three holes, or something," Lickliter said.
We next investigated the mechanism by which the Spire proteins mediate asymmetric spindle positioning.
We conclude that Spire1 and Spire2 mediate asymmetric spindle positioning by assembling the cytoplasmic actin network.
We show that Spire1 and Spire2 first mediate asymmetric spindle positioning by assembling an actin network that serves as a substrate for spindle movement.
