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In the negative clonal selection model (case 4), I introduce the input parameter NRFLN-D (Nreduced fitness loci net-dominant), which is an indicator of the vulnerability of the genome to mutations which may reduce cellular fitness [17].

Maintenance of intracellular NAD+ pools may reduce cellular injury.

Moreover, suppression of inflammation may reduce cellular dysplasia, thereby preventing malignancy.

Thus, the augmented reactive oxygen species production may reduce cellular antioxidant defences.

These observations suggest that miR-223 may reduce cellular adhesion and promote proliferation of cancer cells as previously determined for miR-135b.

The goal is to establish and maintain a baseline state of hyper-osmolality (300 to 320 mOsms/L) and hypernatremia (150 to 155 mEq/L), which may reduce cellular swelling and the number of ICP crises.

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Acidosis may also reduce cellular respiration and oxygen consumption [ 11], which may further benefit a supply/demand imbalance.

Preventing this damage using ice recrystallization inhibitors may greatly reduce cellular injury during cryopreservation and enhance the recovery of specialized cellular functions.

Anti-androgenic hormone therapy in prostate cancer may thus reduce cellular leucine uptake and leucine-mediated mTORC1 activation.

This putative mechanism, in addition to Hotair-triggered transcriptional repression, may further reduce cellular miR-568 in invasive breast cancer cells.

Looking at our motor neuron models, we observed that GE reduced the paralysis and neuronal degeneration phenotypes caused by the expression of mutant mTDP-43 or mFUS and reduced the fraction of insoluble mutant proteins (Fig. 1D I), suggesting that GE may reduce the cellular load of toxic misfolded proteins.

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