MDA-MB-231 cells exposed to apigenin exhibited changes in cellular morphology that may indicate a cellular stress.
This discrepancy between the increase in BAL neutrophils and cellular protein content may indicate that cellular protein content changes are relatively modest in alveolar epithelial cells.
Rapid telomere shortening may indicate a cellular hyper-activation, hyper-proliferation and/or hyper-secretory phenotypes often associated with cellular senescence, stem cell exhaustion and diseases of aging.
Therefore increased cap numbers may indicate further cellular proliferation.
The enhanced DA receptor levels together with the downregulated Comt expression therefore may indicate a cellular effort to compensate abnormal DA signal transduction.
The only putative motif of the deduced protein of EED1, which may indicate a cellular function, is a central glutamine-rich region similar to the S. cerevisiae protein Def1 [29], [30], [30], which may facilitate interactions with other proteins.
Connective tissue growth factor (CTGF), a gene associated with wound-healing [19], was up-regulated (3.49 fold) in senior dogs consuming PPB, which may indicate increased cellular damage or need for epithelial repairs in the aged colon.
In agreement with this, a recent study indicated that in CJD PrPSc glycoforms ratio significantly correlated with the genotype at codon 129 of the prion protein gene [49] Thus, strain-specific PrPSc glycosylation profiles could arise from a complex interaction between PrPC, PrPSc and the cell, and may indicate the cellular compartment in which the strain-specific formation of PrPSc occurs [29].
The variations in exosome content may indicate specific cellular exosome functions.
In glioma patients, high CD4+ TIL levels with low CD8+ TIL levels may indicate suppressed cellular immune responses, which may lead to failure of the current treatment strategy.
