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Researchers report that the protein corona may affect cellular interactions10, cytokine expression11 and protein function12, which further disturbs regular metabolism and organ function13.
Hormone replacement therapy with the gonadal steroid estrogen or synthetic agents such as raloxifene, a selective estrogen receptor modulator, may affect cellular function in brains of postmenopausal women.
Since glycerol kinase has been suggested to exhibit additional activities than glycerol phosphorylation, expression level perturbation in this enzyme may affect cellular physiology globally.
In this review, a summary of piezoelectricity in different biological tissues, mechanisms through which electrical stimulation may affect cellular response, and recent advances in the fabrication and application of piezoelectric scaffolds will be discussed.
Therefore, we postulate that BaP + FL may affect cellular Ca(2+) levels and subsequently cardiac muscle function, potentially underlying BaP + FL cardiotoxicity.
Family members are thought to have similar target specificity [21] and may affect cellular physiology in a common fashion.
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A very broad range of physical and biological properties have been engineered into HA PEG hydrogels that may differentially affect cellular "outcomes" of survival, synthesis and metabolism.
However, due to the high sensitivity of cellular redox-based systems which maintain free-radical homeostasis (e.g. glutathione/glutathione disulfide), if these biomaterials modify the cellular redox environment, they may inadvertently affect cellular compatibility and/or oxidative stress defenses.
This could be problematic because the random integration site of the BAC transgene may alone affect cellular function [28], and the number of integrated copies determines Cre recombinase expression levels in neurons with low and high DAT levels [29].
Not surprisingly, therefore, alcohol also can alter the state of the cellular membranes and may thereby affect cellular function.
These results suggest that the presence of ROS may profoundly affect cellular response to apoptosis and autophagy.
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