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Alternatively, rapamycin may decrease cellular metabolism in anoxia, which would indicate that the effect of rapamycin was not due to its effects on respiration.

Third, potential confounders such as hypothermia, which may decrease cellular respiration and, therefore, CO2 generation [ 21], might have affected the results.

In sensitive MCF-7 cells, SIRT3 can be significantly increased following exposure to Tam, and transfection of MCF-7 cells with a SIRT3 expression plasmid may decrease cellular sensitivity to Tam and block the Tam-induced apoptosis.

Thus, these data suggest that lovastatin may decrease cellular Cho concentration in ML-infected macrophages by acting in two different moments of Cho metabolism: inhibiting HMGCR and decreasing exogenous Cho uptake.

While sulfation and glucuronidation reactions may protect the cell from the mitogenic and DNA-damaging activities of E2 and catecholestrogens, those reactions also compete with methylation of 2-hydroxyestradiol (2-OHE2) and thus may decrease cellular pools of the antiproliferative 2-MeE2.

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Metformin may also decrease cellular hypoxia of less perfused tissues by decreasing oxygen consumption.

This structural variation would impact the phosphorylation of Ser142 by p38 kinase and may potentially decrease cellular protection from oxidative stress.

Our data suggest that chemotherapy kills most of actively proliferative cancer cells, but some of cells exposed to drug may develop a potential to decrease cellular proliferation for chemo-resistance by altering miRNA or other molecule expression.

This is consistent with the known activity of insulin to decrease cellular protein degradation, and suggests IDE may act as an intracellular mediator for insulin action.

Melis (2002), Melis (2009), and Polle et al. (2002) suggested that truncating the chlorophyll antenna to decrease cellular absorbance (modelled as DC) decreases wasted light and increases photosynthetic activity, which may increase the hydrogen yield.

CD9 may decrease transformation and cellular motility by suppressing Wnt signaling pathways and altering the expression of integrins and other adhesion molecules[ 54, 55].

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