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Increased vacuum appears to improve the delivery/uniformity of smoke particles into the module well, however vacuum rates greater than 10 15 ml/min/well may not be favourable for biological testing, as increased flow may cause cellular stress.
A considerable amount of hydrogen peroxide (H2O2) is produced during heme degradation, which may cause cellular toxicity and DNA damage (Quincozes-Santos et al., 2013; Wagener et al., 2003).
ATP may cause cellular degeneration and death, mediated by P2X and P2Y receptors.
As far as GSH is concerned, increased levels of MGO may cause cellular depletion of GSH due to hemithioacetal formation.
Acutely toxic doses may cause cellular death and result in developmental defects or fetal death.
Coggins suggested that low doses may cause cellular abnormalities, such as cell breakdown, delay of cell division and mitochondrial disturbances.
Similar(42)
Accumulation and misincorporation of oxidative damaged 8-oxo-7,8-dihydroguanine triphosphates (8-oxo-dGTP) in genomic DNA may cause serious cellular function disorders.
H2O2 or ATO may cause extensive cellular damage while exerting biological functions through selective signaling molecules.
The time frame should be long enough to enable infection of a maximum number of cells, however, prolonged exposure may cause unwanted cellular toxicity and may also increase the chance of multiple integrations [63], [64].
It causes loss of nuclear stiffness, and the loss of a physical interaction between nuclear lamins and the cytoskeleton may cause general cellular weakness (Broers et al., 2004).
Therefore, dysfunction of RECQL4 may cause reduced cellular proliferative potential, leading to severe damage in the highly proliferative tissue, as well as lower potential for tissue regeneration.
More suggestions(15)
may revolutionize cellular
may block cellular
may phosphorylate cellular
may protect cellular
may cause momentary
may distort cellular
may facilitate cellular
may modulate cellular
may cause irreparable
may change cellular
may enhance cellular
may affect cellular
may lead cellular
may exhaust cellular
may cause serious
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