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Results in Table 2 suggested that wounding may reduce cell division in leaves.

If breast tumor cell growth is dependent on LRP5Δ, as strongly suggested by the above experiments, an appropriate anti-LRP5 antibody may reduce cell viability as well as β-catenin activity.

In some gliomas, inhibition of EZH2 may reduce cell proliferation, possibly by de-repressing Ink4a/Arf.

A previous study suggested that downregulation of SMC4 may reduce cell proliferation.

Pachymic acid from Poria cocos may reduce cell proliferation and induced apoptosis through mitochondria dysfunction in prostate cancer cells [ 33].

However, our results suggest that auraptene may reduce cell proliferation through the suppression of cyclin D1 in MCF-7 cells and in the rat mammary tumors.

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Both circumstances may reduce cell-matrix interactions, and thus negative trends for cultivation performance could be created.

Together, these effects may further reduce cell growth or cause cell death in certain contexts where the induction of ferroptosis per se is not possible.

In contrast, HER2+ breast cancer is not only receptive to antibody-based therapy, but metformin may directly reduce cell proliferation through the HER2 receptor (23).

Furthermore, increased extracellular glutamate is a major cause of excitotoxic cell death and activation of astroglial group I mGluR may indirectly reduce cell death by preventing a loss of astroglial glutamate transporters and thereby maintaining glutamate removal from the extracellular space [54].

Overexpression of E-cadherin in highly invasive cells may reduce tumor cell invasiveness by decreasing MMP-9 and MMP-2 expression [ 16, 17].

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