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(3) mechanistic studies to define how such aberrant signaling may impact cell survival in culture.
For example altered AR activity may impact cell survival and proliferation.
This grouping may represent a coherent, and possibly coordinated, set of alterations which may impact cell mobility and extracellular interactions.
Floral meristem size may impact cell number that will form carpel primordium and subsequent number [ 10, 11].
Further examinations how modification of Notch signalling may impact cell plasticity and differentiation remain to be explored in future.
In addition to trying to understand why local and/or global concentration may impact cell engagement with a surface, mechanisms by which ligand receptor bonding regulates downstream cell behavior can be further explored.
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Oxidative stress may also impact cell membranes, so that enzymes may leak to a higher degree from cells.
Recent results indicate that, in addition to chemical, spatial and mechanical cues, substrate physical cues such as gradients in surface energy may also impact cell functions, such as neuronal differentiation of PC12 cells.
Altogether they form a pattern of colon-cancer specific alterations that may particularly impact cell motility.
cAMP response element-binding protein may also directly impact cell survival by binding to CREs in the promoters of anti-apoptotic factor genes such as BCL-2 to induce their transcription (Wilson et al, 1996).
The zebrafish model used by Davis and Ramakrishnan does not include adaptive immune cells that may impact effector cell activity such as alternative or classical macrophage activation [53].
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