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Future studies will concentrate on MPAs designed to improve circulation to the outer retina which may decrease cell loss.

We hypothesized that the high viscosity of pre-gelled solutions typically used in these applications may decrease cell viability due to the high shear forces required to mix cells with these solutions.

Thus, therapies which enhance CHIP E3 ubiquitin ligase activity or inhibit BAG5 function within dopaminergic neurons and other neuronal populations susceptible to α-syn-mediated toxicity may decrease cell death and slow the progression of neurodegeneration in PD.

These observations suggested to us that NeoA may decrease cell adhesion, which was confirmed by quantifying the dose-dependent inhibition of MDA-MB-231 cell attachment to both collagen type I and fibronectin (Figure 2B).

The possible underlying mechanisms by which Siah1 and Siah1L may decrease cell survival upon radiation exposure seem to be multifaceted.

As expected, L-NAME did not prevent the inhibitory effect of MTX on cell proliferation, since L-NAME itself may decrease cell proliferation in the intestinal epithelium [ 46].

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We assume that MRJ and/or HSP70 knockdown may decrease cell-surface uPAR resulting in less interaction between uPAR and vitronectin.

The loss of αB-crystallin function may also decrease cell viability because αB-crystallin negatively regulates apoptosis by inhibiting caspase 3 activation [37].

This suggests that the proapoptotic function of PKR under the stress of growth factor deprivation conditions may also decrease cell invasion.

In contrast to the current paradigm for GLI1 expression and tumor progression, one study found GLI1 expression may actually decrease cell motility in advanced PDAC (Joost et al., 2012).

A quantity for tumour response was formulated assuming that an effective treatment may decrease the cell proliferation rate (cytostatic) and/or increase the cell loss rate (cytotoxic) of the tumour.

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