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Storage lesion of red blood cells (RBCs) includes alteration of the plasma composition, together with changes in morphology of RBCs resulting in reduced deformability, which together may reduce tissue oxygen availability and have pro-inflammatory and immunomodulatory effects [1].
Thus, the activation of STA-21 may reduce tissue inflammatory patterns, osteoclastic activity, and the consequent bone resorption.
Upregulation of miR-155 in synovial fibroblasts represses the expression of MMP-3 and MMP-1, which may reduce tissue damage [ 31].
The placement of the VSD for 4 weeks following surgery may reduce tissue contraction and stabilise the suture lines of the vaginal epithelium overlying the mesh.
Thus, the activation of STA-21 may reduce tissue inflammation pathways and may further reduce osteoclastic activity and the related bone resorption.
The 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity of CAPA, as shown by an EC50 of 18.6 ± 3.2 μM (comparable to the EC50 of 15.6 ± 2.0 μM of CAPE, data not shown), may reduce tissue oxidative stress and increase tissue availability of NO.
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Thus, blocking apoptosis may strongly reduce tissue damage, however, may not be sufficient to block APAP-induced cellular damage.
HLIF allows thorough decompression as well as realignment and interbody fusion for patients with DS and may help reduce tissue trauma in comparison to other minimally invasive lumbar fusion techniques.
The tumour-associated trypsin inhibitor (TATI), synonymous with serine protease inhibitor Kazal type 1 (SPINK1) and pancreatic secretory trypsin inhibitor (PSTI; Huhtala et al, 1982), balances and inhibits trypsin specifically and may thus reduce tissue destruction (Wiksten et al, 2005).
This naturally occurring process could be related to the aging of mammals as the accumulation of senescent cells may contribute to reduce tissue functionality and may affect its morphology [ 3].
Image-based brachytherapy enables radiation oncologists to precisely prescribe radiation doses for tumors, without increasing unnecessary irradiation to normal tissues, which may reduce normal tissue morbidity.
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