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Specifically, it is thought that their function in sterol metabolism may influence membrane permeability to alter ion homeostasis [ 19].

The PLA2 activity is proposed to accelerate turnover of phospholipids, which may influence membrane changes that occur during apoptosis [ 52].

Along with molecule diameter and differences in lipophilicity, molecular weight may influence membrane permeability, thus causing differences in distribution (Wittsiepe et al. 2007).

For example, activation of the Ras or Src oncogenes is associated with changes in the lysosomal distribution, density, size, ultrastructure, and content, all of which may influence membrane stability [ 24, 90, 91, 98].

It is well known that changes in lipid composition may influence membrane function by regulating protein and lipid membrane homeostasis [ 195– 197], and PUFAs either as constituents of membrane phospholipids or free molecules contribute to membrane chemophysical features (i.e., membrane organization, ion permeability, elasticity, and microdomain formation).

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It can be assumed that deletion of nlpD in Y. pestis may influence membrane-related functions, such as TTSS activity, which is known to be essential for Y. pestis virulence, and thus could lead to the attenuated phenotype.

Serving various functions, cellular organelles maintain redox control unique to each compartment and may also influence membrane permeability to H2O2 [18].

HSPGs may also influence membrane trafficking indirectly, perhaps by regulating signaling events that impinge on trafficking processes.

While these negative charges may not be sufficient to change the net charge of the erythrocyte surface, they may influence the membrane distributions of other charge-bearing molecules.

Alternatively, the expression of APP may influence cell membrane fluidity, because APP is reported to bind cholesterol [ 56] and control its turnover [ 46], so it is possible that aggregated tau may be able to pass through cell membrane with altered fluidity to reach the cytoplasm, where it functions as seeds for intracellular tau aggregation.

Caspases are important members in apoptosis mediated cell death and it is well-known that the ROS level may influence the membrane potential in mitochondria, and these caspases in mitochondria induce release of pro-apoptotic factors by caspase cascade activation [ 57].

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