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Changed insulin sensitivity is a biological mechanism that may link membrane fluidity to diabetes risk.
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The ability to interact with multiple signaling molecules places Abi1 at a position that may link signals from membrane receptors to intracellular networks.
Molecular docking study with Patchdock server revealed that this peptide could interact with the lipid aliphatic chain of 1-palmitoyl-2-oleoyl-phosphoethanolamine (POPE) bilayer and may linked to membrane distortion as we have reported earlier.
Localization of HKI and HKII to the outer mitochondrial membrane is associated with increased phosphorylation of glucose, suppression of apoptosis and maintenance of mitochondrial membrane potential, and may link glycolytic glucose metabolism to oxidative phosphorylation via use of intramitochondrial ATP to phosphorylate glucose [ 30].
Tetraspanins are known to organize other proteins into membrane microdomains and may link to the actin cytoskeleton via EWI (Glu-Trp-Ile) and ERM (ezrin radixin moesin) proteins (Hemler 2003; Sala-Valdés et al. 2006).
Finally, it is appropriate to mention another interesting possibility that may link mitochondrial Ca2+ dysfunction to ALS pathogenesis: the vesicle-associated membrane protein (VAMP -associated protein B (VAMP -associatedound to be mutated in familial ALS [174].
Endothelial dysfunction may link these two processes.
They may link to her.
Thus, it may function in similar conserved processes and act as a multifunctional scaffold in protein complexes linking membrane receptors to intracellular pathways.
It has been suggested to function in linking membrane to membrane and membrane to cytoskeleton [ 33].
Interestingly, the requirement for actin in CME may be linked to membrane tension.
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CEO of Professional Science Editing for Scientists @ prosciediting.com