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This cation influx may cause membrane depolarization [ 36].
Fink and colleagues [ 50] suggested that TPP-conjugated antioxidants would have limited utility in patients with sepsis since the mitochondrial depolarization sometimes seen during sepsis may result in poor uptake of TPP-conjugated antioxidants into mitochondria and increasing the dose may cause membrane depolarization through accumulation of the cation.
Similar(58)
By indiscriminately inhibiting cholesterol synthesis in the nervous system, Lipitor may indirectly cause membrane degeneration and contribute to adverse neuromuscular problems.
Yet, faulty membrane depolarization as reported in various tissues of critically ill patients may cause reduced membrane excitability as well.
A very large Rgas may cause the membrane dehydration and subsequently a low cell performance.
Compressed damage by overloading the integrity of the cartilage ECM may cause cell membrane damage and eventually cell death.
The phenotype of accumulated GFP-SNB-1 in exoc-8 animals resembled greatly that of unc-18 animals, suggesting that they may cause similar membrane accumulation in cells.
One theoretical concern with this therapeutic approach is the possibility that inducing muscle hypertrophy may cause additional membrane stress to already fragile muscle fibers, thereby further inducing damage.
Although exudative changes derived from CNV may cause epiretinal membrane (ERM) formation, which can also cause tractional force at the vitreo-retinal interface, there have been few reports of AMD-associated macular hole development in which the full thickness of the retinal tissue is completely torn by the tractional force.
This may cause reduced membrane fusion or cell-wall establishment reflected in the formation of incomplete cell walls that can be observed in mutants defective in KNOLLE-interacting SNAREs, in sterol biosynthesis and drp1a mutants (Lauber et al, 1997; Schrick et al, 2000, 2002, 2004; Collings et al, 2008; Men et al, 2008).
To investigate whether heat-treatment of cells after transfer to Elispot plates during SCA (Klohn et al, 2003), a treatment known to cause membrane delipidation, may explain these inconsistencies, we treated fixed cells with delipidating solvents prior to immunolabelling with anti-PrP antibody ICSM18.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com