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The final common pathway may include endothelial dysfunction, inflammation, cytokine overproduction and growth factor deficiency [ 1].
The mechanisms by which acute inflammation may affect the risk of vascular events are uncertain but may include endothelial dysfunction.
Further mechanisms of regional blood flow regulation may include endothelial shear stress [ 29] and the release of vasoactive substances by red blood cells [ 30].
Potential sources of TXB2 may include endothelial cells activated by shear stress or catecholamine activated platelets, however the source was not determined in this study.
Biological mechanisms linking long-term air pollution exposure to chronic damage of the cardiovascular system may include endothelial dysfunction and vasoconstriction, increased blood pressure, prothrombotic and coagulant changes, systemic inflammatory and oxidative stress responses, autonomic imbalance and arrhythmias, and the progression of atherosclerosis.
Similar(55)
Once more, there might be evidence of the "very discussed" pleiotropic effects of statins [ 33]; these effects may include reduced endothelial inflammation, nitric oxide production enhancement, and improved insulin sensitivity [ 34].
The current study shows that increases in endothelial Nox2 levels may contribute significantly to the development of angiotensin II-induced hypertension through mechanisms that may include alterations in endothelial vasodilator function and/or an enhancement of vascular structural remodeling.
However, putative underlying mechanisms may include chronic inflammation, endothelial dysfunction, vascular smooth muscle proliferation, and impaired nitric oxide generation (27– 27).
The present study suggests that the biological pathways associated with PE may include immune response, coagulation, endothelial dysfunction as well as lipid metabolism.
Mechanisms of in vivo angiostasis remain to be fully elucidated but may include the induction of endothelial cell apoptosis [ 10, 11] and the inhibition of the recruitment of angiogenic factor-producing leukocytes [ 12].
The other consequences of endothelial activation may include microcirculatory dysfunction, which might compromise cerebral perfusion [27].
Related(20)
may involve endothelial
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may preserve endothelial
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may include surgical
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may include cost-of-living
may include retail
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may affect endothelial
may include biometric
may include several
may promote endothelial
may induce endothelial
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