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It also may improve endothelial function and thereby ameliorate the distributive defect.
Among the proposed mechanisms, steroids may improve endothelial function [47], preserve the glycocalyx [49], or decrease rolling and adhesion of white blood cells to the endothelium [50].
Statins may improve endothelial function by modulating the production of reactive oxygen species [ 7].
These multiple actions of AG may improve endothelial function in diabetes independent of its AGE-inhibiting activity [ 22, 23].
Glucagon like peptide-1 (GLP-1) receptor agonist treatment may improve endothelial function via direct and indirect mechanisms.
From a theoretical point of view, antidiabetic medications may improve endothelial function [ 212], and may also via this mechanism improve the functionality of pulmonary vasculature and gas diffusion.
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A potential pitfall in this study was the inclusion of patients receiving infliximab, which may itself improve endothelial function [ 29].
85 Moreover, findings from both experimental and clinical studies reported that chronic or daily use of PDE5 inhibitors for ED may significantly improve endothelial dysfunction.
SGLT-2 inhibitors may also improve endothelial function or the vascular architecture, that is, collagen, elastin, advanced glycation end-products and other components of connective tissue that participate in the process of arterial stiffening.
In addition to hypotriglyceridemic effects, omega-3 fatty acids may attenuate inflammation, improve endothelial function and reduce thrombus formation [ 148, 149].
Despite the prevalence of endothelial dysfunction in diabetes and evidence that walnut consumption may improve both endothelial function and biomarkers of cardiovascular disease risk in patients with hypercholesterolemia, no studies have investigated the effect of walnut intake on endothelial function in type 2 diabetes.
More suggestions(15)
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