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The pathogenesis of encephalopathy may involve endothelial activation and cardiovascular dysfunction.
Taken together, these results suggest that an increase in endothelial levels of Nox2 contributes significantly to hypertension in settings where there is increased activation of the renin-angiotensin system, an effect that may involve endothelial dysfunction and/or vascular structural remodeling.
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We explored further whether the previously observed relationship between the group A-like var subgroup expression and IC [ 10] may involve widespread endothelial activation.
Indirect effects may involve downregulated perfusion by endothelial dysfunction [ 40].
Given the growing attention to cell-to-cell communication via microparticles shed by apoptotic or activated cells, we hypothesized that endothelial cell survival and proliferation of mouse lung endothelial cells may involve the interactions with microparticles and their cargo.
These data suggest that the previous reported cardiovascular benefits of metformin may involve an improvement of the endothelial glycocalyx.
Loss of estrogen-dependent cardiovascular protection diminishes endothelial function, and may involve activation of the renin-angiotensin system (RAS).
Neo-blood vessel growth (angiogenesis), which may involve the activation of pre-existing endothelial cells (EC) and/or the recruitment of bone marrow-derived vascular precursor cells (BM-VPC), is essential for tumor growth.
Indirect effects may involve downregulated perfusion by induction of endothelial dysfunction [ 35, 48].
In addition to antithrombotic effects, the elevation of uPA in sepsis may involve the VEGF pathway, which includes endothelial cell repair and migration, angiogenesis, and vascular permeability change.
One explanation for this phenomenon may involve an antiproliferative effect toward the endothelial cells, but the antitumour effects that occurs in vivo may be also due to putative interactions of the extracellular region of BAI1, since it is known to contain five thrombospondin type I repeats and of a RGD motif that is recognized by integrins.
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