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and pathways which may affect endothelial function and thus trigger the development of hypertension.
Whether higher K+ concentration and longer exposure may affect endothelial NO production, however, remains unknown.
Conversely, in chronic inflammation, inflammatory cells produce cytokines and growth factors that may affect endothelial cell functions.
Thus, because repetitive PPHG is thought to cause cardiovascular events [ 46, 48], ameliorating PPHG may affect endothelial function and prevent cardiovascular events [ 22, 38, 46].
Given the increased MDA levels in Sirt3-deficient mice Sirt3 may affect endothelial relaxation, thereby affecting the initial disposition for atherogenesis.
Inflammatory cells, namely monocytes, macrophages, T lymphocytes and neutrophils, fully participate in the angiogenic process by secreting cytokines that may affect endothelial cell functions, including proliferation, migration and activation.
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Antiatherogenic effects of estrogens are partially due to inhibition of vascular smooth muscle cells growth, proliferation, and contractility and may also affect endothelial cell regeneration and angiogenesis [100 103].
ACE inhibitors may positively affect endothelial dysfunction by decreasing angiotensin II production alone.
These findings indicate that CVD risk factors may differentially affect endothelial and smooth muscle cell function, particularly in the macrovasculature.
There is evidence that hypovitaminosis D may adversely affect endothelial function [ 12], leading to increased aortic stiffness [ 13].
$$\end{document} The authors postulated that the training-induced decrease in circulating antioxidant levels may adversely affect endothelial function in the highly trained or overtrained state.
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