On the other hand, expression of Sirt3 in cancer cells may impart resistance to 'environmental' or therapeutic stress, thereby contributing to the maintenance of the stability of cancer cells' mitochondrial genome and tumor survival and progression.
The inherent properties of stem/progenitor cells may impart their transformed counterparts with the ability to evade traditional antitumor therapies and to establish metastasis [ 3- 5].
Even different clones of a particular cell line may impart subtle changes on a mAb molecule, and only the original mAb-encoding DNA clone and master cell bank can be guaranteed to generate a consistent product, provided culture conditions are carefully maintained.
These results suggest that neither changes to proliferation nor cell death are major contributing factors to RPE loss and, therefore, that Yap activity may impart RPE identity upon bi-potential optic vesicle cells.
These findings strongly suggest in addition to Wnt signaling, RXRalpha, and other signaling may impart BBB specific properties to CNS endothelial cells.
These findings suggest mechanisms by which increased BP1 may impart a survival advantage to breast cancer cells, which could lead to increased resistance to therapeutic agents in patients.
Further elucidation of the biological features of these putative tumor initiating cells with radical survival capacity and tumorigenic potential may impart new insights on factors that drive sudden acquired drug resistance.
However, these exogenous biomaterials may impart unforeseeable cell biomaterial interactions, uneven degradation, inflammatory responses, and infection, or may limit cell adhesion [ 37].
Apical cytoplasmic blebs or snouts are often present at the luminal surface of the epithelial cells and, in some cases, may be prominent or exaggerated, which may impart an irregular contour to the luminal aspect of the acini.
It is possible that one or more CD44 members may impart adverse cellular characteristics, potentially through activation of erbB or other receptors, onto tumour cells whilst other members may have a neutral or even tumour inhibitory role.
