It was postulated that this activity may decrease host tissue viscosity to facilitate diffusion of salivary pharmacological components through the dermis, and/or to produce small DNA fragments that have been demonstrated to have anti-hemostatic activity [ 40].
Although the mode and optimal dose of melatonin is still not clear, effective radioprotective actions show that including melatonin as an adjuvant in radiation therapy may decrease the normal tissue damage induced by irradiation, which leads to more tumor control by use of higher doses of irradiation during radiotherapy.
It is known that each voxel contains hundreds of alveoli and its image represents an overall behaviour of all these units; consequently, a collective presence of non-aerated and aerated alveoli in the same voxel may decrease the gas:tissue ratio but not enough to indicate collapse [ 19].
Physical activity "may decrease exposure of breast tissue to estrogen" and "may also affect cancers of the colon, breast and other sites by improving energy metabolism," or the burning of calories.
Use of somatic tissue may decrease detection of Wolbachia.
Blood viscosity is increased by RBC transfusion and this may decrease oxygen transport to tissues [ 6, 20, 21].
However, the host inflammatory response and other endogenous molecules released in response to tissue injury may decrease MSC-mediated protection.
The lack of iNOS may decrease NO production in adipose tissue in an autocrine/paracrine way, thereby increasing the expression of UCPs and hence energy expenditure.
TH is thought to minimize the release and the effect of free radicals, excitatory neurotransmitters and protease cascades during reperfusion of ischemic brain tissue, and may decrease vasoconstriction and intravascular thrombosis leading to potential ongoing micro-ischemia [ 2].
This may be due to decreased tissue oxygen delivery associated with microcirculatory dysfunction, or may occur via alterations in cellular energy pathways and mitochondrial function, resulting in a decreased ability to utilise the available oxygen – a phenomenon termed cellular dysoxia [ 1].
