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Central Europeans exhibit selection of specific ATXN2 CAG-repeat alleles that do not result in a different protein sequence, but may affect transcript or protein abundance (40).
In addition, we found 606 SNPs in splice sites that may affect transcript splicing and possibly protein sequence and function.
Because some UTR-SNPs may affect transcript and protein abundance, their knowledge could somehow bridge a gap between differential gene expression studies and cancer phenotype evidences.
More research is needed to clarify the specifics of any functional divergence between grape duplicated AP genes, and new factors that may affect transcript divergence and how different factors work together are worth investigation.
We recently found that PTBP2 is expressed in neuronal progenitors, while NOVA is induced in post-mitotic neurons (Yano et al., 2010; Licatalosi et al., 2012); regulation of cryptic exon splicing may affect transcript levels in neurons and/or prevent spurious expression of transcripts in non-neural cells.
Similar(55)
These three codons are toward the 5' end of the transcript where translation may affect transcription.
Physical separation can be prohibitively expensive, however, and may itself affect transcript abundance levels.
Thus, EDM2 and WNK8 may either affect transcript levels of other components of the respective regulatory pathways or affect them by playing roles other than transcriptional regulation.
NMD may also affect transcript read counts associated with severe leaky or inactivated natural donor sites, which produce exon skipping with frame-shifting.
These analyses suggest that the uncoupling of protein and transcript levels for 'biogenesis'-related genes has a central role in the aging process, and may affect the transcript and protein abundances of other genes, as elaborated upon in the discussion.
Thirdly, in addition to pathogenic processes, a number of factors may affect blood transcript abundance and confound the analysis.
Related(19)
may affect evidence
may affect conversion
may affect translation
may impact transcript
may affect proceedings
may affect timing
may affect reading
may produce transcript
may indicate transcript
may suggest transcript
may enforce transcript
may include transcript
may complicate transcript
may reflect transcript
may improve transcript
may be transcript
may alter transcript
may ensure transcript
may affect transcriptional
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