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Presence of the 4q12 amplicon and subsequent over-expression of PDGFRA might serve as predictive markers for efficacy of sunitinib.
Identification of predictive markers for efficacy and/or toxicity could lead to more tailored therapy and, ultimately, improved treatment outcomes.
Therefore, we tried to identify the predictive markers for efficacy of bevacizumab in gastric cancer patients by using bevacizumab-sensitive and insensitive tumor models.
If indeed there is a link between hypertension and effectiveness of the drug, biomarkers for toxicity may also serve as markers for efficacy.
Consequently, ESR and CRP values cannot be used as isolated surrogate markers for efficacy in SpA patients, even for those with elevated ESR and CRP values at baseline.
For example, pharmacogenetic markers for efficacy of ondansetron, which were found in a study of alcoholics of European descent (Johnson et al. 2011), are more prevalent in individuals with African ancestry and rare to nonexistent in East Asians.
Similar(54)
Mediastinal nodal sterilization (MNS) after induction chemoradiotherapy (CRT) can serve as an intermediate marker for efficacy.
The proliferation marker Ki67 is another marker of interest to be used as a surrogate marker for efficacy, especially with endocrine therapy [ 17, 32, 33].
Also, evaluation of SV2C (as well as other candidates) as a marker for efficacy will be conducted in the E5103 trial, as efficacy data become available.
This surrogate marker for efficacy has never been validated in suitably sized studies, and the optimal levels for critically ill patients are not known.
To further explore thyroid dysfunction as a possible surrogate marker for efficacy, the determination of TSH might have been important in the above-mentioned study.
Related(20)
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