The comparative genomics approach has enabled us to identify SNPs and other variable regions in Pae that offer candidate molecular markers for large scale phylogenetic analyses.
However, analyses of large data sets of eastern [ 31, 32] and northern Asian complete mtDNA sequences [ 19- 21, 30, 33, 34] have significantly refined the topology of the mtDNA phylogeny, providing new informative markers for large scale population studies.
Additionally, this study meets all the criteria proposed for evaluating the use of molecular markers for large scale germplasm diversity analyses [ 35]; a large number of markers, thorough representation of these markers on a genetic linkage map of the species and the selection of monolocus probes.
The molecular markers chr11-7240 and chr11-9030 were used as selection markers for large-scale mapping (Figure 3B and 3D).
Overgo probes have been gaining popularity as markers for large-scale physical mapping of both plant and animal genomes.
Overgo probes have gained in popularity as markers for large-scale physical mapping of both plant and animal genomes [ 15, 16].
But still, the use of SNP markers for large-scale genome studies in allogamous forage grass species such as perennial ryegrass is still in its infancy.
A total of 1773 TF gene-encoding transcript sequences of chickpea ICC4958 were mined for microsatellite repeat motifs and used to design both the genic TFGMS and TFFDMS markers for large-scale genotyping applications.
Once mapped, the genome sequence around the locus can be used to design additional genetic markers for fine-scale mapping, and to identify putative candidate genes using the genome annotation.
24 Furthermore, the dense distribution of SNPs across the genome makes them ideal markers for large-scale genome-wide association studies to discover genes in common complex diseases, such as cancer.
