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Many pathological situations escape this prerequisite.
Although bone tissue has the capacity to regenerate, bone repair is impaired in many pathological situations.
Dysfunction of vascular endothelium is implicated in many pathological situations.
Many pathological situations are determined by the balance between such survival and apoptotic signals.
Our laboratory is involved in the study of the cellular response to hypoxia, a condition of low oxygen tension that characterizes many pathological situations [ 9].
Importantly, there are many pathological situations when crosstalk between different cell death subroutines has a significant role, and treatment of all of these disorders is based on the attempt to either suppress or induce cell death.
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EC apoptotic death-induced loss of EC number and EC dysfunction may constitute an initial causative step in, and have a critical role in, the progress of many vascular pathological situations by compromising vascular wall permeability to cytokines, growth factors, lipids and immune cells, increasing smooth muscle cell proliferation and enhancing blood coagulation [6] [8].
Previous studies performed by our research group about GMG-ITC activity have revealed a wide range of effects and applications of the compound in many experimental pathological situations [ 16, 17, 30].
Although bone tissue possesses the capacity for regenerative growth, the bone repair process is impaired in many clinical and pathological situations.
Hemodynamic shear stress from blood flow on the endothelium critically regulates vascular function in many physiological and pathological situations.
The opening of hemichannels occurs in response to many physiological and pathological situations, including volume regulation, proliferation, calcium wave propagation by extracellular messengers and cell death during metabolic inhibition (reviewed in [ 53]).
Related(20)
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