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Integrins have also been implicated in many pathological settings, for example in cancer development [10] [13].
(2) More recently, it has been shown that levels of CoA species are perturbed in many pathological settings including diabetes, hyperoxia, seizures, 7) and various inherited metabolic disorders.
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Mediating the expansion of vascular beds in many physiological and pathological settings, angiogenesis requires dynamic changes in endothelial cell behavior.
Cell migration plays an important role in many physiological and pathological settings, ranging from embryonic development to cancer metastasis.
Advanced glycation end products (AGEs) have been implicated in diverse pathological settings of many diabetic complications, and the possible mechanisms have been widely reported.
Autophagy plays important roles in various physiological settings, and disruption of autophagy has been shown to lead to many pathological conditions (Winslow and Rubinsztein, 2008; Hussey et al., 2009; Mizushima and Komatsu, 2011; Jiang and Mizushima, 2014; Martin et al., 2014).
Many of the signaling molecules have attracted considerable interest in the past because of their role in diverse pathological settings including autoimmune diseases, inflammation or cancer.
Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing.
MMPs can remodel extracellular matrix components in many pathological conditions.
Here we review evidence of roles for NF-κB in the regulation of developmental and synaptic plasticity, and cell survival in physiological and pathological settings.
Extracellular matrix interactions have essential roles in normal physiology and many pathological processes.
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