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IL-17 has been involved in many pathological features that play a role in SSc pathology including the secretion of pro-inflammatory cytokines, the recruitment of monocytes and the triggering of granulocyte-macrophage colony-stimulating factor [23], [24].
Although multiple sclerosis is a uniquely human disease, many pathological features can be induced in experimental autoimmune encephalomyelitis (EAE) models following induction of central nervous system-directed autoimmunity.
The HDM model shares many pathological features with persistent human asthma, notably eosinophilic airway inflammation, mucus hypersecretion, fibrosis of the airway wall and airway hyperreactivity (AHR) to methacholine [5].
AMD and AD share many pathological features including accumulation of Aβ, increased oxidative stress, and apoptotic cell death.
Intriguingly, AMD has many pathological features that are common to Alzheimer's disease (AD), including the deposition of β-amyloid (Aβ) peptide [ 6].
Many pathological features have been identified as being of prognostic value and therapeutic significance and, as a consequence, there are numerous guidelines stating which pathological features should be reported for colorectal cancer (Henson et al, 1994).
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Thus, Curionopolis and Itacaiunas viruses share many pathological and clinical features present in other rhabdoviruses but distinct virulence and glial targets in newborn albino Swiss mice brain.
Interestingly, comparative histology indicates that the synovitis of early RA shares many of the pathological features of established disease [55].
Female NZB/NZW F1 mice spontaneously develop an autoimmune disease, which has many of the pathological features of human SLE.
There is considerable evidence to suggest that endothelin (ET -1 is a kET -1rtisipant in many of the pathological features of SSc.
This subgroup shares many clinical and pathological features with the so called 'basal-like' subgroup according to gene expression profile analysis, first described by Perou et al. [ 10].
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