Sentence examples for many pathological states from inspiring English sources
Endothelial dysfunction occurs with many pathological states, including sepsis, thrombotic thrombocytopenia purpura, pulmonary hypertension, sickle cell diseases, activation of the complement C5-9 membrattacktacomplexlex and exposure to cytotoxic chemotherapy among others [108 110].
We applied this method to NF-κB, a family of dimeric transcription factors that plays central roles in immune responses, cell survival and aging, and its dysregulation is linked to many pathological states.
This justifies the proposal that thiamine supplementation should be envisaged in many pathological states, especially in elderly patients.
Although primarily known to be associated with inflammation, TNFα now occupies a central place in the crosstalk of many pathological states.
This molecule is critical for multiple physiological functions, yet plays a role in many pathological states, including neurodegenerative disease and cancer.
Thromboxane A2 (TxA2) is a major, unstable arachidonic acid metabolite, and plays a key role in normal physiology [3] but is additionally implicated in many pathological states such as unstable coronary artery disease and severe unstable angina [4].
In addition, many other pathological states are associated with hyperuricemia, including metabolic syndrome, heart failure, pulmonary disorder and type 2 diabetes mellitus [68].
Many of the pathological states of critically ill patients lead to relative immunosuppression, with impairment of the ability of neutrophils to kill bacteria [ 8].
In many RACK1-associated pathological states, aberrant RACK1 signaling, which underpins the condition, arises from either increased or decreased expression of the scaffolding protein (reviewed in [ 2]).
Impairment of the protein trafficking and delivery mechanisms causes endothelial dysfunction and is characteristic of many pathological and disease states such as atherosclerosis, diabetes, hypertension, inflammation and tumour metastasis [ 83, 84].
Therefore, it may serve as a fundamental synaptic apparatus for generating neuronal synchronizations in the neocortex, and hence could be important to many relevant physiological and pathological states.
