Sentence examples for many developmental regulators from inspiring English sources

Importantly, these gene targets include many developmental regulators, a subset of which, encoding transcription factors and chromatin modifying activities, are associated with RNA polymerase II and are expressed in ES cells.

By promoting the activity of many developmental regulators, Hsp90 may simply be positioned as a passive regulator of interactions between multiple developmental pathways and competing genetic and environmental effects.

Genome-wide studies of PcG protein binding have revealed that indeed many developmental regulators are PcG protein targets and are repressed in ES cells, with many of them 'held-in-check' by H3-K4me3/H3-K27me3 bivalent chromatin domains that are later resolved in a lineage specific fashion.

Indeed, many developmental regulators act as dimers that can take up larger areas on DNA.

Another set of reports, in which the chromatin profile of ES cells, somatic stem cells and their differentiated progeny were contrasted, provided collective evidence that many developmental regulators genes in ES cells are primed for future expression, being marked with histone modifications associated with both active and repressed chromatin [ 19, 20].

These data suggests that in TS and XEN cells, many developmental regulator genes remain 'accessible' - as reflected by the prevalence of early replicating loci - similar to that reported previously for ES cells [ 19].

PcG proteins are known to modify the chromatin structure around their binding sites by marking the chromatin of their target genes through methylation at lysine 27 of histone H3; these sites include the promoters of many developmental regulator genes, leading to gene repression [ 20].

Pax6, as many other developmental regulators, depends on a substantial number of cis-regulatory elements in addition to its promoters for correct spatiotemporal and quantitative expression.

Similar to Drosophila blastoderm nuclei, the pluripotent properties of human embryonic stem cells are reflected by the presence of paused Pol II complexes on a wide number of genes, including many key developmental regulators [2].

This is supported by the recent discovery that cis-regulatory associations for many critical developmental regulators such as Grem have been conserved throughout animals (Irimia et al. 2012).

The stalling of RNA polymerase II (RNAPII) at the promoters of many genes, including developmental regulators, stress-responsive genes, and HIVLTR, suggests transcription elongation as a critical regulatory step in addition to initiation.