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Notch receptors are involved in the regulation of cell fate decisions, differentiation and proliferation in many developmental systems.
In many developmental systems, spatial pattern arises from morphogen gradients, which provide positional information for cells to determine their fate.
N-signalling is essential to pattern formation and cell fate determination in many developmental systems [1] [3].
Furthermore, since in many developmental systems DNA methylation and histone H3K9 methylation pathways can be dependent on one another, an interesting question is whether these two chromatin regulatory mechanisms would also be linked on the Xi [ 28].
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The aggregating slime mold system provides an interesting model to explore this mechanism, which has relevance in many other developmental systems.
The developing metanephric kidney is a model system for many developmental processes, including reciprocal inductions between different cell types, mesenchymal-to-epithelial transitions (METs) and patterning (Saxen, 1987).
This is in vitro system displays many developmental events observed in vivo (Livera et al. 2006) and supports the independent study of the dose- and time-related effects on somatic and germ cells of fetal testes.
Prenatal alcohol exposure produces many developmental defects of the central nervous system (CNS), such as in the corpus callosum (CC).
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans.
Indeed, many developmental studies reported the importance of the proprioceptive system for postural control in children [7].
Light regulates many developmental and physiological processes in both plant and animal systems.
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