ESCs, for instance, are known to share certain cellular and molecular signatures similar to those of cancer cells [ 2], and deregulation of ESC-associated transcriptional regulators has been implicated in many human developmental diseases.
3D amoeboid cell migration is central to many developmental and disease-related processes such as cancer metastasis.
Among these species, the zebrafish is emerging as a pre-eminent model vertebrate for the in vivo analysis of many developmental and disease mechanisms.
Misregulation of apoptosis is linked to many developmental defects and diseases such as tumour formation, autoimmune diseases and neurological disorders.
In addition to their roles in A/P patterning, PcG and trxG proteins are involved in many developmental processes and diseases [4] [7].
DOI: http://dx.doi.org/10.7554/eLife.07068.018 Hh and Sema3-Nrp signaling are simultaneously involved in many developmental processes and diseases.
For many developmental processes and diseases, detailed neuropathological studies have localized the brain region in which to survey the transcriptome.
Failure to produce adequate mature ECM or form proper collagen fibers can lead to many developmental defects and diseases, such as osteogenesis imperfecta – which is typically characterized by fragile bones, scoliosis, short stature, hearing loss and teeth defects (Rauch and Glorieux, 2004).
Given the importance of NOTCH1 receptor protein in many developmental, homeostasis, and disease pathways, and to skeletal muscle formation in particular, - we focused on the DNA and chromatin epigenetics of NOTCH1 and other Notch signaling genes.
