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Many developmental genes are still active in specific tissues after development is completed.
Large K27HMD regions of length >4 kbp suppress the expression of many developmental genes [ 8].
Many developmental genes are arranged in gene complexes each comprising a small number of functionally related genes.
The fibrosarcomas in this study were part of subcluster S and a weak expression signature including many developmental genes distinguished these tumors from the remaining STS.
Microarray analysis indicates that sticky and dFmr1 are both required for regulation of many developmental genes in a variety of cell types.
With CSMinfinder, we identified large K27HMD regions in the medaka and human genomes [ 8, 16, 17] that overlapped many developmental genes.
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Many developmental gene pathways have been found to occur or be activated during regenerative processes [ 22, 23].
PcG proteins are known to modify the chromatin structure around their binding sites by marking the chromatin of their target genes through methylation at lysine 27 of histone H3; these sites include the promoters of many developmental regulator genes, leading to gene repression [ 20].
Although we have identified "reliable" SNPs in only a subset of our UniGenes (and not necessarily those most interesting from the point of view of development), we now have gene sequence tags for many developmental candidate genes in which we can develop markers and determine the relative position on a linkage map for the 28 chromosomes of B. anynana.
As many early developmental genes are located in broad domains of Polycomb-associated H3K27me3 (Nègre et al., 2011), many of our putative enhancers are found within large regions containing high levels of this repressive mark.
Stewart et al. established that many developmental regulatory genes involved in fin regeneration are poised in a bivalent H3K4me3/H3K27me3 chromatin domain, and that the demethylation of H3K27me3 enables activation of expression of these genes in response to injury.
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many developmental transitions
many such genes
many developmental processes
many developmental checkpoints
many developmental problems
many developmental defects
many developmental studies
many developmental abnormalities
many developmental events
many human genes
many developmental systems
many developmental diseases
many developmental milestones
many developmental enhancers
many developmental psychologists
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