Sentence examples for major genetic effect from inspiring English sources

Multiple variants at the aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) loci have also been well documented as genes of major genetic effect especially in East-Asian populations [12], [13], [14], [15].

Although this analysis indicated that the major genetic effect on chromosome 17 maps outside the H2 region it is still possible that the H2 locus could contribute to the observed phenotype.

As the major genetic effect of the FHB resistance genes is additive, it should be possible to accumulate different genes to enhance FHB resistance in wheat (Bai et al. 2000).

Genetic mapping of cell cycle duration revealed a four-locus genetic model, including a major genetic effect on chromosome 12, which accounts for 75% of the inherited phenotype variation.

However, the results of the quantitative trait GWAS demonstrate that the sample size used was sufficient to detect a major genetic effect such as that manifested at the MSTN locus.

The authors observed no major genetic effects of the analysed variants on depressiveness.

In one example, adaptive differentiation of native insects flushing on invasive plants arose from rapid epistatic divergence of novel, major genetic effects (Carroll et al. 2003).

It is well established that LD based association analysis is effective only for the genes underlying Mendelian traits or the genes with major genetic effects on polygenic traits [ 23, 33].

24 Even with the warfarin story, although major genetic effects have been identified, inclusion of these into models with clinical variables remains only moderately predictive of warfarin dose required or time to stabilise international normalised ratio.

The absence of clear evidence of major genetic effects, despite (high) estimates of heritability for major psychiatric disorders, together with evidence of "causal" environmental exposures resulting in changes in gene expression is consistent with the concept that the biologic underpinnings of psychiatric disorders are epigenetic in form rather than DNA sequence based [ 50].

This could be interpreted to mean that in these mutation negative families individual non-genetic risk factors such as parity and menarche still contribute to risk in the context of a strong family history but rather more weakly, even in aggregate, than as yet undetected major genetic effects.