Sentence examples for major genetic instability from inspiring English sources

The two major genetic instability pathways include microsatellite instability (MSI) and chromosomal instability (CIN) [ 8].

The two major genetic instability pathways of the carcinogenesis of gastric cancer were CIN and MSI.

Current knowledge on the molecular mechanisms underlying gastric carcinogenesis indicates one major epigenetic instability pathway and two major genetic instability pathways [ 8].

The majority of eukaryotic studies specific to ZnO NPs, however, have relied heavily on the use of immortalized cells lines, which are recognized to display altered sensitivities to foreign materials/chemicals due to alterations in metabolic processes and major genetic instabilities.

Three major forms of genetic instability in CRC have been described [2], [3], [4].

Two major models of genetic instability have been described.

Two major types of genetic instability are described in gastric cancer, chromosomal instability and microsatellite instability[ 1].

Chromosomal instability (CIN) and microsatellite instability (MIN) are the two major forms of genetic instability in colorectal cancer.

For the first time, we determined the relationship between telomere length and tumour progression and location, as well as its relationship to MSI and p53 mutation status, two markers of major pathways of genetic instability in CRCs.

All these data indicate that the type and the level of genetic instability are major determinants of outcome for breast cancer.

This observation is relevant because long GAA/TTC tracks, that cause Friedrich's ataxia [ 39], for example, elicit profound mutagenic, genetic instability and major recombination behaviors.