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We concluded that the intervening physical region between 19.33-19.86 Mbp of the reference rice genome harbors the major genetic factor directing the floury endosperm characteristics of Suweon 542.
This study revealed a unifying major genetic factor.
Therefore, if HVP is influenced by a major genetic factor, GWAS may be able to dissect its genetic basis.
Within this direction, recent publications also suggest that genomic rearrangements are a major genetic factor underlying prostate cancer [ 47].
Among these, aberrations of chromosome 1 have been established as the second major genetic factor for the initiation/progression of meningiomas and correlate with increased morbidity [ 31, 32].
This suggests that the major genetic factor conferring resistance through CYP6M7 could be located in a trans regulatory region rather than in the coding sequence, but this regulator remains to be found.
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The major genetic factors affecting the expression of newly introduced genes in transgenic plants including epigenetic effects are summarized.
Some of the major genetic factors involved in immune response associated with uveitis include HLA genes and non-HLA genes such as CTLA-4, ILs, and KIR.
It is important to understand whether a combination of the major genetic factors would contribute more to T2DM or may be used to stratify high-risk populations [14] [18].
Antigen presenting cells have long been considered associated to diabetes susceptibility [32], [33] due to their exclusive expression of MHC class II molecules, the major genetic factors underlying T1DM.
Under the assumption that all the major genetic factors have already been discovered and that there are no gene-gene or gene-environment interactions, we can estimate the number of variants that will suffice to obtain a ROC curve with an AUC as large as the theoretical genetic maximum.
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