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The model that includes a three-way epistatic interaction as the primary genetic effect yields a diversity of machine learning performance results with AUCs ranging from a low of 0.53 for the naïve Bayes method and a high of 0.67 for the classification tree.
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Fetal gene therapy may correct the primary genetic defect.
Chromosomal effects of integration deserve attention after a report on late occurrence of leukaemia in children treated with retroviral vectors for severe combined immunodeficiency, after successful correction of the primary genetic defect.
Among the Han Chinese population, the genetic effect was primary found in men but not in women.
miRNAs appear to be components of both the genetic architecture of these complex phenotypes as well as integral parts of the biological pathways that mediate the effects of primary genetic deficits.
These data underscore the importance of the systemic effects of a primary genetic heart disease to other organs and provide insight into potentially novel therapeutic interventions for HCM.
Understanding the context in which a genetic effect operates is not a primary target in GWAS.
Because this analysis was not the primary aim, however, the power to detect our observed genetic effect on BMD changes in tamoxifen-treated patients was <20%.
In combination with high-density single nucleotide polymorphisms, quantitative trait locus (QTL) mapping and genetic effect analysis were performed for five yield factors (spikelet number per panicle, primary branches per panicle, secondary branches per panicle, plant height, and panicle length) to explore the genetic mechanisms underlying the formation of the giant panicle of R1128.
These data suggest that the effects of a mutationally activated FLT3 receptor may be different, depending on a primary genetic alteration or the composition of different genetic alterations in addition to the FLT3-LM.
Whether due to a primary (genetic) or secondary (acquired) deficiency, absent or diminished enzyme activity allows undigested sugars to accumulate in the lumen of the small intestine, resulting in the clinical effects of sucrase-isomaltase deficiency [12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com