Sentence examples for major causative role from inspiring English sources

Helicobacter pylori (HP) is an accepted cause of chronic active gastritis and has a major causative role in peptic ulcers.

The Bcr Abl fusion protein, playing major causative role in chronic myeloid leukemia (CML), is a cytoplasmic oncoprotein that contains an N-terminus oligomerization domain (OD) mediating homodimerization of Bcr Abl proteins, and an intact OD in Bcr Abl is required both for the activation of its transforming activity and tyrosine kinase.

Similarly to dyspeptic subjects, exhibit multiple gastrointestinal motility defects, in which fibrosis and anatomical alterations might play a major causative role, rather than a simple neuro-muscular dysfunction.

This result allowed authors to sustain that the families considered are genetically enriched for extreme survival and that it is unlikely that environmental factors play a major causative role in familial longevity.

In those experiments, however, a major causative role in degeneration was ascribed to the miswiring of neurons due to cell migration defects (Ohshima et al., 1996; Takahashi et al., 2010).

In the case of obesity per se, however, we see no major evidence as yet for a causative role of deranged iron metabolism or chelation in causing obesity.

However, in T-cells the SME model, where methylation takes an active causative role, is the major contributor.

Recently, causative role of encephalitis in major psychotic features, dyskinesias (particularly orofacial), seizures, and autonomic and respiratory changes has been emphasized [ 1, 2].

Causative role of encephalitis in major psychotic features, dyskinesias (particularly orofacial), seizures, and autonomic and respiratory changes has been recently emphasized.

Oxidative DNA damage induced by reactive oxygen species is a major source of mutation load in living organisms and is believed to play a causative role in aging and degenerative diseases such as cancer (1, 2).

Psychiatric disorders have been ascertained to be a major causative factor for SB [ 1- 3], and the treatment is expected to play an important role in reducing SB recurrence and preventing suicide [ 1].