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Haplotype 2 is clearly the major causative haplotype.
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Since AD is a common neurodegenerative disorder, affecting globally about 3% of people older than 60 years in the world [37], even a small risk associated with mtDNA haplotype could have major causative implications at a population level.
Ciguatoxins are the major causative toxins of ciguatera seafood poisoning.
Filamentous fungi are major causative of mycotic keratitis.
The streptococcal species are the major causative agents of the dental caries.
Maternal trisomy 21 ovarian mosaicism might provide the major causative factor for fetal Down syndrome.
Enterovirus 71 (EV71) is one of the major causative agents for hand, foot, and mouth disease.
Noroviruses are major causative agents of sporadic and outbreak-associated nonbacterial gastroenteritis worldwide.
Vibrio parahaemolyticus is a major causative agent of human gastroenteritis in seafood products including shrimps.
Staphylococcus aureus is a major causative agent implicated in outbreaks of food poisoning.
Human noroviruses are major causative agents of sporadic and epidemic gastroenteritis both in children and adults.
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