Sentence examples for primary causative role from inspiring English sources

Thus it would be prudent to treat the suggestion that Aβ plaques have a primary causative role in synapse destruction in human LOAD with caution.

Zivadinov and colleagues concluded that CCSVI was unlikely to have a primary causative role in MS. Despite lack of reproducibility among investigators, patients with MS have undergone endovascular balloon and stent venoplasty procedures to correct venous abnormalities.

Thus, as with plaques, it is conceivable that Aβ oligomers play a role, but it would also be prudent to treat the suggestion Aβ oligomers play a primary or sole causative role in synapse destruction with a degree of caution.

Such studies will also provide increased insight into the sequence of RPE change relative to the other parts of the tunica ruyschiana and more definitively determine not only the role of ischaemia as a primary causative factor of AMD but allow us to determine the role of pharmacological agents that could have a beneficial effect on the development and progression of AMD.

In addition to respiratory tract and systemic infections, HBoV DNA sequences are frequently detected in fecal samples during primary infections (3, 4 ), although a causative role in viral gastroenteritis has not been established (5 – 7 ).

It has been suggested that biochemical mediators produced by the primary tendon cells (tenocytes) in response to stress may play a causative role 1 2; a theory supported by studies showing that tenocytes express enzymes related to synthesis of classically neuronal substances, such as acetylcholine and catecholamines.

This suggests that apoptosis is not the primary causative mechanism governing the hematopoietic cell abnormalities caused by the TERT deficiency.

Obesity plays a causative role in the pathogenesis of coronary artery disease (CAD), including primary atherosclerotic and restenotic changes after coronary artery bypass grafts (CABG).

These newly emerging coral diseases, either caused or associated with members of the Vibrionacae family have sparked a debate on the origin of Vibrio pathogens and their role in the aetiology of coral diseases: Are Vibrio pathogens the primary causative agents of all these diseases?

Helicobacter pylori (HP) is an accepted cause of chronic active gastritis and has a major causative role in peptic ulcers.

The causative role of HBoV1 has been questioned because of HBoV1 DNA presence after primary infection and common co-infection with other respiratory viruses (1 – 5 ).