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Epigenetic mechanisms maintain cell identity and function, and guide cell fate decisions during hematopoiesis 15.
The role of epigenetic regulators such as PRCs is not to establish but rather to maintain cell identity by providing stability to transcriptional programs.
Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNAs are key regulators of gene activity states; therefore, epigenetic disruptions can affect transcription of the genes that establish and maintain cell identity and proliferation capacity.
The 14 mutants in this class are divided into two subcategories (Table 2): The 10 mutants in this class develop normal cell layers and reach an appropriate number of sporogenous cells but are not able to maintain cell identity throughout development and cells die prematurely.
The occluded state could be quite stable in order to maintain cell identity over the entire ontology of the organism (the germline being an exception where the occluded state is either never fully established for most genes or is erased during gametogenesis).
Similar(55)
Runx2 is a member of the Runt-related transcription factor family, which establishes and maintains cell identity.
Thus, RIP140 is a key determinant in maintaining cell identity in the mammary epithelium.
Accordingly, lncRNAs can play a crucial role in maintaining cell identity.
PRC1 is thus important for maintaining cell identity and controlling developmental transitions.
Different cell types are regulated by sets of TFs that are important for establishing and maintaining cell identity.
Epigenetic memory is a natural mechanism involved in maintaining cell identity through multiple cell divisions and is thus essential in maintaining stability of cellular identity in an organism.
Related(20)
maintain compartment identity
preserve cell identity
retain cell identity
maintain tissue identity
safeguarding cell identity
maintains cell identity
preserving cell identity
maintain cell integrity
maintain cell permeability
maintain cell wall/cell
maintain cell cycle
maintain cell wall
maintain cell survival
maintain cell redox
maintain cell specificity for
maintain cell pluripotency
maintain cell morphology
maintain cell phone
maintain cell homeostasis
maintain cell activity
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