Sentence examples for maintain cell pluripotency from inspiring English sources

They form protein complexes that maintain cell pluripotency by repressing the expression of differentiation genes.

More recently, the importance of quantitative data has become increasingly clear because expression of the Oct4 gene (also previously indicated as Pou5f1or Oct3/4) is necessary to maintain cell pluripotency via a stringently dose-dependent regulatory process.

The Pluri genes retrieved in this analysis include genes previously shown to maintain cell pluripotency like Yes, Cd9, Esrrb, Tcl1 and Tbx3 [ 21, 25, 33, 39]) and many novel genes (summary in Figure 8).

A distinct set of transcription factors (Sox2, Oct4, Nanog) are responsible for maintaining cell pluripotency and undifferentiated phenotypes of cells.

Therefore, transcriptional regulation of target genes by OCT4 is very complicated, and it is necessary to understand the key gene network that maintains cell pluripotency in embryo development and governs cell differentiation and proliferation in cancer progression.

ZIC2 is a member of a family of zinc-finger transcription factors, which are involved in early neuronal development and may be involved in maintaining cell pluripotency (Warr et al, 2008; Brown and Brown, 2009; McMahon and Merzdorf, 2010).

Y. Zhou et al. report that a hypoxic microenvironment can maintain cell proliferation capacity, enhance pluripotency, and promote differentiation, indicating that effective cell isolation and expansion under hypoxic conditions may be a viable technique for autologous cell-based therapies.

Although LIF-signaling is sufficient to maintain ES cell pluripotency in serum conditions, LIF is insufficient to maintain ES cell pluripotency in serum-free conditions.

The authors concluded that the ability of Oct4 to maintain ES cell pluripotency is derived from the ancestral function of this class of proteins to maintain multipotency during early vertebrate development.

It is also reported to maintain stem cell pluripotency by activating the Jak2/Stat3 pathway and increasing the efficiency of induced pluripotent stem cells generation [ 8].

Recently, Bdph was reported to provide neuroprotection by reducing the release of various proinflammatory molecules from activated microglia [ 9], Bdph was also reported to maintain stem cell pluripotency by activating the Jak2/Stat3 pathway and to increase the efficiency of induced pluripotent stem cells generation [ 10].