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Overall, these data argue that over-expression of Rv2744c increases resistance of M. smegmatis to peptidoglycan-disrupting antibiotics, possibly helping to maintain cell wall homeostasis.
Thus, in pathogenic fungi, the ability to maintain cell wall integrity is critical to the establishment of disease within the host.
We postulate that proteolytic cleavage of the 35-kDa antigen by PepD helps maintain cell wall homeostasis in Mycobacterium and regulates specific stress response pathways during periods of extracytoplasmic stress.
To maintain cell wall integrity, new polymers are synthesized simultaneously and added to the growing wall.
Indeed, it has been reported that fungi can overcome damaged cell walls by increasing chitin content to maintain cell wall integrity [ 44].
Post transcriptional regulation of enzymes involved in cell wall synthesis and cell division might also significantly contribute to a quick and efficient adaptation of the cell to maintain cell wall homeostasis.
Similar(53)
Although cell wall proteins are minor components in SCWs, they play essential roles in maintaining cell wall strength and confer appropriate properties to cell walls25.
Slt2/Mpk1 is the MAP kinase that responds to cell wall stress and plays an important role in maintaining cell wall integrity [14].
In addition, heat shock activates the MAP kinase homolog Mpk1 that maintains cell wall integrity and prevents cell lysis when cells are grown at elevated temperature [33].
Melanin has a role in the structure and stability of the conidial cell wall [61] and it is conceivable that hyphal melanin may be involved in maintaining cell wall stability in response to stress.
Because mutants with defects in cell wall integrity, such as cna1Δ, mpk1Δ, and ras1Δ, are hypersensitive to fludioxonil [7], [19], we also examined the role of Hrk1 in maintaining cell wall integrity.
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