Sentence examples for improper differentiation from inspiring English sources

These results suggest that the 10-fold reduction in CD8+ Tm cell generation with low level of Ag presentation is not due to the improper differentiation of naïve CD8+ T cells into effectors.

Close up examination of the brain revealed improper differentiation, such as an enlarged forebrain, indistinct isthmic constriction at the midbrain-hindbrain boundary (mhb), and a malformed hindbrain (Figure 1A, right panel).

In drosophila, uncontrolled JNK activity impairs epithelial gut integrity (Seisenbacher et al., 2011) and causes improper differentiation in the aging intestine (Biteau et al., 2008).

Removal of Nup358 from developing neurons leads to improper differentiation and generation of multiple axons, while overexpression of a Nup358 fragment important for interaction with Dvl and aPKC leads to significant abrogation of the process of differentiation.

Together, our results demonstrate an essential role for egr-5 in the proper spatial and temporal progression of progeny cells in the epidermal lineage and that misexpression of these marker domains likely causes improper differentiation and failed epidermal maturation.

In addition, inappropriate restore mechanisms, improper terminal differentiation or apoptosis of lung stem cells may be a reason for pathology of CLD.

Craniofacial defects are often observed in conjuction with cardiac defects and both phenotypes are thought to be caused by improper migration and differentiation of neural crest cells [36], [37].

The etiology of tumors is multifactorial, and is believed to be the result of inappropriate cell growth, faulty cell differentiation and improper cell cell and cell extracellular matrix interactions.

An anti-proliferative effect of a RUNX1 mutant protein may have an oncogenic effect due to an improper balance between proliferation and differentiation.

Therefore, any transcriptional or processing disturbance during the earlier stage of cloned embryo and extra embryonic lineage differentiation due to improper reprogramming of specific regulatory molecules responsible for global transcription, processing and maturation of miRNAs could be a potential reason for global down regulation of miRNAs in NT or IVP derived placentas.

Lineage selection produced large populations of SOX2+ neural stem/progenitor cell populations and neuronal derivatives while directed differentiation produced few and improper neuronal derivatives.